Epigenetics in inflammatory rheumatic diseases
نویسندگان
چکیده
منابع مشابه
Epigenetics in inflammatory rheumatic diseases.
Inflammatory rheumatic disorders, such as rheumatoid arthritis (RA) and connective tissue diseases, are characterized by chronic inflammation that generally can be overcome by lifelong administration of immunosuppressive therapies. In most of these diseases, factors of genetic predisposition have been described, in particular the influence of distinct HLA haplotypes. In addition, environmental ...
متن کاملEpigenetics in rheumatic diseases
With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumat...
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OBJECTIVES Rheumatic diseases encompass a wide range of conditions of poorly characterized etiopathology, many having both genetic and environmental susceptibility factors. Epigenetic studies are providing new insights into disease pathogenesis. Recent rheumatology literature related to DNA methylation studies-both epigenome-wide and candidate gene-are discussed, as well as methodological issue...
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Epigenetics is a key mechanism regulating the expression of genes. There are three main and interrelated mechanisms: DNA methylation, post-translational modification of histone proteins and non-coding RNA. Gene activation is generally associated with lower levels of DNA methylation in promoters and with distinct histone marks such as acetylation of amino acids in histones. Unlike the genetic co...
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The pattern of chronic inflammatory rheumatic diseases seen in 52 black Zimbabweans was determined. These diseases constituted 2% of all treatable chronic endemic medical diseases registered around Gweru City. Rheumatoid arthritis (RA) and gout were the commonest, 38.8% and 28.8% of the total respectively. Systemic lupus erythematosus (SLE), polymyositis, progressive systemic sclerosis, mixed c...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2007
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.22948